Background: Between 6 to 12% of people with cholelithiasis also have choledocholithiasis. Pimary bile duct closure and T-tube drainage are two options available for closure of choledochotomy after common bile duct exploration. The aim of this meta-analysis was to analyze the outcomes of primary choledochorrhaphy versus T-tube drainage after common bile duct exploration for choledocholithiasis.
Methods: A systematic literature search was conducted using Embase, MEDLINE, Cochrane, and PubMed databases on all randomized controlled trials (RCT), published between January 1980 and September 2012, reporting perioperative outcomes after primary choledochorrhaphy versus T-tube drainage after common bile duct exploration.
Results: Eight RCTs were included comprising of 619 patients. Primary choledochorrhaphy was found to reduce the length of stay (weighted mean difference 95% confidence interval (CI), -1.09 [- 1.59 to – 0.60]; p < 0.0001), overall complications (odds ratio (OR) 95% CI, 0.47 [0.28, 0.80]; p = 0.005), positive bile culture (OR 95% CI, 0.58 [0.10, 0.45]; p < 0.0001) compared to T-tube drainage. Whereas no significant differences were found in retained bile duct stones (OR 95% CI, 0.60 [0.23, 1.57]; p = 0.30), mortality (OR 95% CI, 0.44 [0.10, 1.81]; p = 0.25), biliary leak (OR 95% CI, 0.58 [0.23, 1.42]; p = 0.23) and subhepatic collection (OR 95% CI, 1.06 [0.30, 3.68]; p = 0.93).
Conclusion: Primary choledochorrhaphy should be the method of choice after choledochotomy for common bile duct exploration as it is associated with reduced length of stay and overall complications compared to T-tube drainage.